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HLA-G protein and IVF treatments

HLA-G protein and IVF treatments


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In vitro fertilization is the most important factor that increases the success of embryos. Some studies show that a proteinHLA-G protein that plays a role in maintaining immune tolerance between the mother and the baby increases uterine attachment and clinical pregnancy rates. Memorial Hospital IVF Center Director Dr. Contact semra directly shares interesting data with you.

To what extent do embryo selection and placement affect the success of IVF treatment?

Scientists carry out studies aiming to increase pregnancy rates to higher levels by using new techniques. However, the wide variety of factors causing infertility makes it difficult to increase the success rate. Some of the transferred embryos cannot attach to the inner surface of the uterus, and some of the ones that can be attached end up with miscarriage in the early period.

In almost all IVF centers, the selection of embryos to be transferred is based on the development and structural characteristics of the embryos. In embryo selection using structural evaluation methods, embryo quality and ability to attach to the uterus can only be measured to a certain extent. For this reason, embryo selection according to similar criteria does not result in pregnancy in some cases, but in some cases multiple pregnancy can be achieved. These results show that selection criteria are not sufficient to determine embryo selection for each infertile couple. Of course, not only embryo quality is evaluated but also many clinical data are evaluated. In addition, the transfer of multiple embryos to increase the pregnancy rate increases the risk of multiple pregnancy which is one of the most important complications of IVF treatment.

What are your criteria for embryo selection?

Numerous embryos are obtained by IVF treatment. It is very important to make the right choice among these embryos and to transfer the least possible number of quality embryos to the mother. As mentioned before, the method we use today to select the embryo is to examine the embryos under microscope and to select them according to their structural characteristics. However, this method alone is not enough. In addition to embryo selection criteria, various studies have been carried out to date in order to find a new parameter that can be measured easily. The most remarkable of these is the relationship between HLA-G (Human leucocyte antigen G) protein and the ability of the embryo to attach to the internal uterus tissue and pregnancy.

Can you give us information about HLA-G protein?

HLA-G protein is a protein that plays a role in ensuring immune tolerance between mother and baby. This protein secreted by the placenta cells during pregnancy; It prevents the baby developing in the mother's uterus from being rejected by the mother's immune system. Therefore, it is thought that detection of HLA-G protein in culture environments where embryos continue to grow can give us positive information about the continuity of these embryos. It is predicted that embryos that do not have HLA-G protein in culture are less likely to cause pregnancy.

Are there any researches on this subject?

It has been observed that the HLA-G protein secreted by the embryo increases the rates of uterine attachment and clinical pregnancy rates. But there are also groups that advocate otherwise. These scientists believe that the HLA-G protein secreted by the embryo may not have a direct effect on embryo attachment and pregnancy rates. However, it is not possible to examine the results clearly since the embryos that secrete HLA-G protein and the embryos that do not secrete HLA-G protein but are of good quality are transferred together.

As Istanbul Memorial Hospital IVF and Genetic Center, we are conducting scientific studies in our R & D laboratory for the development of new techniques. When we prove them scientifically, we put them into practice in our clinic and laboratory. For this purpose, we are conducting an experimental study that examines the HLA-G protein on which intensive research is continuing. In order to investigate the possible relationship between the embryo's potential to attach to the uterine internal tissue and clinical pregnancy and to determine its usability in the clinical field, approximately 100 patients have been conducted in our center for 6 months with the approval of the patients. At the end of the study, the results will be presented in the scientific arena.


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